Faecal carriage of oxyiminocephalosporin-resistant Enterobacteriaceae among paediatric units in different hospitals in the south of France
Identifieur interne : 000196 ( Main/Exploration ); précédent : 000195; suivant : 000197Faecal carriage of oxyiminocephalosporin-resistant Enterobacteriaceae among paediatric units in different hospitals in the south of France
Auteurs : A. Boutet-Dubois [France] ; A. Pantel [France] ; M.-F. Prere [France] ; O. Bellon [France] ; N. Brieu-Roche [France] ; E. Lecaillon [France] ; A. Le Coustumier [France] ; A. Davin-Regli [France] ; L. Villeneuve [France] ; N. Bouziges [France] ; E. Gleize [France] ; R. Lamarca [France] ; C. Dunyach-Remy [France] ; A. Sotto [France] ; J.-P. Lavigne [France]Source :
- European journal of clinical microbiology & infectious diseases : (Print) [ 0934-9723 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
The aim of this study was to determine the presence of oxyiminocephalosporin-resistant (OCR) Gram-negative bacilli and extended-spectrum β-lactamase (ESBL)-producing isolates in stool specimens obtained from paediatric patients hospitalised for acute diarrhoea. We conducted a prospective, multicentre study over a period of 6 months in seven hospitals in the south of France. Samplings were carried out from infants admitted for acute diarrhoea with no previous antibiotic treatment in the last week. Bacteria in stool specimens were screened for the presence of OCR Gram-negative bacilli on Drigalski agar supplemented with ceftazidime and ESBL CHROMagar® media, and confirmed by the Rosco tablets test. Genetic detection was performed by the Check MDR® microarray and by polymerase chain reaction (PCR) and sequencing with bacterial DNA extracted from isolates. The presence of OCR enterobacteria was markedly high (177/1,118 patients, 15.2 %), with an important community origin (66.1 %). The majority of multidrug-resistant (MDR) bacteria were Enterobacter cloacae (106, 59.9 %) and Escherichia coli (61, 34.5 %). The prevalence of ESBL and CTX-M producers represented 5.2 and 4.3 % of the isolates, respectively. The main proportion of these ESBL carriers was found in children less than 1 year of age (53.4 %). One carbapenemase (IMP-1) was detected. The study revealed the wide dissemination of MDR bacteria in infants attending hospitals in the south of France during a non-outbreak situation, in particular, the spread of cefotaximase and the detection of a carbapenemase. This worrisome situation must reinforce the use of hygiene procedures and appropriate antibiotics to control the emergence and spread of OCR organisms.
Affiliations:
- France
- Languedoc-Roussillon, Languedoc-Roussillon-Midi-Pyrénées, Midi-Pyrénées, Provence-Alpes-Côte d'Azur
- Aix-en-Provence, Aubagne, Cahors, Narbonne, Nîmes, Perpignan, Toulouse
- Université Montpellier 1
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000051
- to stream PascalFrancis, to step Curation: 000717
- to stream PascalFrancis, to step Checkpoint: 000039
- to stream Main, to step Merge: 000199
- to stream Main, to step Curation: 000196
Le document en format XML
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Boutet-Dubois</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier 1, UFR de Médecine, 186 Chemin du Carreau des Lanes, CS83021</s1><s2>30908 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Bactériologie, CHU Carémeau</s1><s2>30029 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName></affiliation></author><author><name sortKey="Pantel, A" sort="Pantel, A" uniqKey="Pantel A" first="A." last="Pantel">A. Pantel</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier 1, UFR de Médecine, 186 Chemin du Carreau des Lanes, CS83021</s1><s2>30908 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Bactériologie, CHU Carémeau</s1><s2>30029 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName></affiliation></author><author><name sortKey="Prere, M F" sort="Prere, M F" uniqKey="Prere M" first="M.-F." last="Prere">M.-F. Prere</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Laboratoire de Bactériologie-Hygiène, CHU Purpan</s1><s2>31059 Toulouse</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Bellon, O" sort="Bellon, O" uniqKey="Bellon O" first="O." last="Bellon">O. Bellon</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Laboratoire de Diagnostic Biologique des Maladies Infectieuses et d'Hygiène, Centre Hospitalier du Pays d'Aix</s1><s2>13616 Aix-en-Provence</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aix-en-Provence</settlement></placeName></affiliation></author><author><name sortKey="Brieu Roche, N" sort="Brieu Roche, N" uniqKey="Brieu Roche N" first="N." last="Brieu-Roche">N. Brieu-Roche</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Laboratoire de Diagnostic Biologique des Maladies Infectieuses et d'Hygiène, Centre Hospitalier du Pays d'Aix</s1><s2>13616 Aix-en-Provence</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aix-en-Provence</settlement></placeName></affiliation></author><author><name sortKey="Lecaillon, E" sort="Lecaillon, E" uniqKey="Lecaillon E" first="E." last="Lecaillon">E. Lecaillon</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Laboratoire de Biologie Polyvalente, Centre Hospitalier Saint Jean</s1><s2>66046 Perpignan</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Perpignan</settlement></placeName></affiliation></author><author><name sortKey="Le Coustumier, A" sort="Le Coustumier, A" uniqKey="Le Coustumier A" first="A." last="Le Coustumier">A. Le Coustumier</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Laboratoire de Biologie, Centre Hospitalier Jean Rougier</s1><s2>46005 Cahors</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">Cahors</settlement></placeName></affiliation></author><author><name sortKey="Davin Regli, A" sort="Davin Regli, A" uniqKey="Davin Regli A" first="A." last="Davin-Regli">A. Davin-Regli</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Laboratoire de Biologic, Centre Hospitalier Edmond Garcin</s1><s2>13677 Aubagne</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aubagne</settlement></placeName></affiliation></author><author><name sortKey="Villeneuve, L" sort="Villeneuve, L" uniqKey="Villeneuve L" first="L." last="Villeneuve">L. Villeneuve</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Laboratoire de Biologic, Centre Hospitalier Edmond Garcin</s1><s2>13677 Aubagne</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aubagne</settlement></placeName></affiliation></author><author><name sortKey="Bouziges, N" sort="Bouziges, N" uniqKey="Bouziges N" first="N." last="Bouziges">N. Bouziges</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier 1, UFR de Médecine, 186 Chemin du Carreau des Lanes, CS83021</s1><s2>30908 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Bactériologie, CHU Carémeau</s1><s2>30029 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName></affiliation></author><author><name sortKey="Gleize, E" sort="Gleize, E" uniqKey="Gleize E" first="E." last="Gleize">E. Gleize</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire d'Analyses Médicales, Centre Hospitalier de Narbonne</s1><s2>11108 Narbonne</s2><s3>FRA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Narbonne</settlement></placeName></affiliation></author><author><name sortKey="Lamarca, R" sort="Lamarca, R" uniqKey="Lamarca R" first="R." last="Lamarca">R. Lamarca</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire d'Analyses Médicales, Centre Hospitalier de Narbonne</s1><s2>11108 Narbonne</s2><s3>FRA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Narbonne</settlement></placeName></affiliation></author><author><name sortKey="Dunyach Remy, C" sort="Dunyach Remy, C" uniqKey="Dunyach Remy C" first="C." last="Dunyach-Remy">C. Dunyach-Remy</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier 1, UFR de Médecine, 186 Chemin du Carreau des Lanes, CS83021</s1><s2>30908 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation></author><author><name sortKey="Sotto, A" sort="Sotto, A" uniqKey="Sotto A" first="A." last="Sotto">A. Sotto</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier 1, UFR de Médecine, 186 Chemin du Carreau des Lanes, CS83021</s1><s2>30908 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation></author><author><name sortKey="Lavigne, J P" sort="Lavigne, J P" uniqKey="Lavigne J" first="J.-P." last="Lavigne">J.-P. Lavigne</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Bactériologie, CHU Carémeau</s1><s2>30029 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">13-0264785</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 13-0264785 INIST</idno><idno type="RBID">Pascal:13-0264785</idno><idno type="wicri:Area/PascalFrancis/Corpus">000051</idno><idno type="wicri:Area/PascalFrancis/Curation">000717</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000039</idno><idno type="wicri:doubleKey">0934-9723:2013:Boutet Dubois A:faecal:carriage:of</idno><idno type="wicri:Area/Main/Merge">000199</idno><idno type="wicri:Area/Main/Curation">000196</idno><idno type="wicri:Area/Main/Exploration">000196</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Faecal carriage of oxyiminocephalosporin-resistant Enterobacteriaceae among paediatric units in different hospitals in the south of France</title><author><name sortKey="Boutet Dubois, A" sort="Boutet Dubois, A" uniqKey="Boutet Dubois A" first="A." last="Boutet-Dubois">A. Boutet-Dubois</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier 1, UFR de Médecine, 186 Chemin du Carreau des Lanes, CS83021</s1><s2>30908 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Bactériologie, CHU Carémeau</s1><s2>30029 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName></affiliation></author><author><name sortKey="Pantel, A" sort="Pantel, A" uniqKey="Pantel A" first="A." last="Pantel">A. Pantel</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier 1, UFR de Médecine, 186 Chemin du Carreau des Lanes, CS83021</s1><s2>30908 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Bactériologie, CHU Carémeau</s1><s2>30029 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName></affiliation></author><author><name sortKey="Prere, M F" sort="Prere, M F" uniqKey="Prere M" first="M.-F." last="Prere">M.-F. Prere</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Laboratoire de Bactériologie-Hygiène, CHU Purpan</s1><s2>31059 Toulouse</s2><s3>FRA</s3><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">Toulouse</settlement></placeName></affiliation></author><author><name sortKey="Bellon, O" sort="Bellon, O" uniqKey="Bellon O" first="O." last="Bellon">O. Bellon</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Laboratoire de Diagnostic Biologique des Maladies Infectieuses et d'Hygiène, Centre Hospitalier du Pays d'Aix</s1><s2>13616 Aix-en-Provence</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aix-en-Provence</settlement></placeName></affiliation></author><author><name sortKey="Brieu Roche, N" sort="Brieu Roche, N" uniqKey="Brieu Roche N" first="N." last="Brieu-Roche">N. Brieu-Roche</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Laboratoire de Diagnostic Biologique des Maladies Infectieuses et d'Hygiène, Centre Hospitalier du Pays d'Aix</s1><s2>13616 Aix-en-Provence</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aix-en-Provence</settlement></placeName></affiliation></author><author><name sortKey="Lecaillon, E" sort="Lecaillon, E" uniqKey="Lecaillon E" first="E." last="Lecaillon">E. Lecaillon</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Laboratoire de Biologie Polyvalente, Centre Hospitalier Saint Jean</s1><s2>66046 Perpignan</s2><s3>FRA</s3><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Perpignan</settlement></placeName></affiliation></author><author><name sortKey="Le Coustumier, A" sort="Le Coustumier, A" uniqKey="Le Coustumier A" first="A." last="Le Coustumier">A. Le Coustumier</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Laboratoire de Biologie, Centre Hospitalier Jean Rougier</s1><s2>46005 Cahors</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Midi-Pyrénées</region><settlement type="city">Cahors</settlement></placeName></affiliation></author><author><name sortKey="Davin Regli, A" sort="Davin Regli, A" uniqKey="Davin Regli A" first="A." last="Davin-Regli">A. Davin-Regli</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Laboratoire de Biologic, Centre Hospitalier Edmond Garcin</s1><s2>13677 Aubagne</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aubagne</settlement></placeName></affiliation></author><author><name sortKey="Villeneuve, L" sort="Villeneuve, L" uniqKey="Villeneuve L" first="L." last="Villeneuve">L. Villeneuve</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Laboratoire de Biologic, Centre Hospitalier Edmond Garcin</s1><s2>13677 Aubagne</s2><s3>FRA</s3><sZ>8 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region><settlement type="city">Aubagne</settlement></placeName></affiliation></author><author><name sortKey="Bouziges, N" sort="Bouziges, N" uniqKey="Bouziges N" first="N." last="Bouziges">N. Bouziges</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier 1, UFR de Médecine, 186 Chemin du Carreau des Lanes, CS83021</s1><s2>30908 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Bactériologie, CHU Carémeau</s1><s2>30029 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName></affiliation></author><author><name sortKey="Gleize, E" sort="Gleize, E" uniqKey="Gleize E" first="E." last="Gleize">E. Gleize</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire d'Analyses Médicales, Centre Hospitalier de Narbonne</s1><s2>11108 Narbonne</s2><s3>FRA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Narbonne</settlement></placeName></affiliation></author><author><name sortKey="Lamarca, R" sort="Lamarca, R" uniqKey="Lamarca R" first="R." last="Lamarca">R. Lamarca</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Laboratoire d'Analyses Médicales, Centre Hospitalier de Narbonne</s1><s2>11108 Narbonne</s2><s3>FRA</s3><sZ>11 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Narbonne</settlement></placeName></affiliation></author><author><name sortKey="Dunyach Remy, C" sort="Dunyach Remy, C" uniqKey="Dunyach Remy C" first="C." last="Dunyach-Remy">C. Dunyach-Remy</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier 1, UFR de Médecine, 186 Chemin du Carreau des Lanes, CS83021</s1><s2>30908 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation></author><author><name sortKey="Sotto, A" sort="Sotto, A" uniqKey="Sotto A" first="A." last="Sotto">A. Sotto</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Institut National de la Santé et de la Recherche Médicale, U1047, Université Montpellier 1, UFR de Médecine, 186 Chemin du Carreau des Lanes, CS83021</s1><s2>30908 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>13 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName><orgName type="university">Université Montpellier 1</orgName></affiliation></author><author><name sortKey="Lavigne, J P" sort="Lavigne, J P" uniqKey="Lavigne J" first="J.-P." last="Lavigne">J.-P. Lavigne</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Laboratoire de Bactériologie, CHU Carémeau</s1><s2>30029 Nîmes</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>10 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Languedoc-Roussillon-Midi-Pyrénées</region><region type="old region" nuts="2">Languedoc-Roussillon</region><settlement type="city">Nîmes</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">European journal of clinical microbiology & infectious diseases : (Print)</title><title level="j" type="abbreviated">Eur. j. clin. microbiol. infect. dis. : (Print)</title><idno type="ISSN">0934-9723</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">European journal of clinical microbiology & infectious diseases : (Print)</title><title level="j" type="abbreviated">Eur. j. clin. microbiol. infect. dis. : (Print)</title><idno type="ISSN">0934-9723</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Child</term><term>Colonization</term><term>Enterobacteriaceae</term><term>Feces</term><term>France</term><term>Hospital</term><term>Infection</term><term>Microbiology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Fèces</term><term>Colonisation</term><term>Hôpital</term><term>Enterobacteriaceae</term><term>Enfant</term><term>France</term><term>Infection</term><term>Microbiologie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this study was to determine the presence of oxyiminocephalosporin-resistant (OCR) Gram-negative bacilli and extended-spectrum β-lactamase (ESBL)-producing isolates in stool specimens obtained from paediatric patients hospitalised for acute diarrhoea. We conducted a prospective, multicentre study over a period of 6 months in seven hospitals in the south of France. Samplings were carried out from infants admitted for acute diarrhoea with no previous antibiotic treatment in the last week. Bacteria in stool specimens were screened for the presence of OCR Gram-negative bacilli on Drigalski agar supplemented with ceftazidime and ESBL CHROMagar® media, and confirmed by the Rosco tablets test. Genetic detection was performed by the Check MDR® microarray and by polymerase chain reaction (PCR) and sequencing with bacterial DNA extracted from isolates. The presence of OCR enterobacteria was markedly high (177/1,118 patients, 15.2 %), with an important community origin (66.1 %). The majority of multidrug-resistant (MDR) bacteria were Enterobacter cloacae (106, 59.9 %) and Escherichia coli (61, 34.5 %). The prevalence of ESBL and CTX-M producers represented 5.2 and 4.3 % of the isolates, respectively. The main proportion of these ESBL carriers was found in children less than 1 year of age (53.4 %). One carbapenemase (IMP-1) was detected. The study revealed the wide dissemination of MDR bacteria in infants attending hospitals in the south of France during a non-outbreak situation, in particular, the spread of cefotaximase and the detection of a carbapenemase. This worrisome situation must reinforce the use of hygiene procedures and appropriate antibiotics to control the emergence and spread of OCR organisms.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Languedoc-Roussillon</li><li>Languedoc-Roussillon-Midi-Pyrénées</li><li>Midi-Pyrénées</li><li>Provence-Alpes-Côte d'Azur</li></region><settlement><li>Aix-en-Provence</li><li>Aubagne</li><li>Cahors</li><li>Narbonne</li><li>Nîmes</li><li>Perpignan</li><li>Toulouse</li></settlement><orgName><li>Université Montpellier 1</li></orgName></list><tree><country name="France"><region name="Languedoc-Roussillon-Midi-Pyrénées"><name sortKey="Boutet Dubois, A" sort="Boutet Dubois, A" uniqKey="Boutet Dubois A" first="A." last="Boutet-Dubois">A. Boutet-Dubois</name></region><name sortKey="Bellon, O" sort="Bellon, O" uniqKey="Bellon O" first="O." last="Bellon">O. Bellon</name><name sortKey="Boutet Dubois, A" sort="Boutet Dubois, A" uniqKey="Boutet Dubois A" first="A." last="Boutet-Dubois">A. Boutet-Dubois</name><name sortKey="Bouziges, N" sort="Bouziges, N" uniqKey="Bouziges N" first="N." last="Bouziges">N. Bouziges</name><name sortKey="Bouziges, N" sort="Bouziges, N" uniqKey="Bouziges N" first="N." last="Bouziges">N. Bouziges</name><name sortKey="Brieu Roche, N" sort="Brieu Roche, N" uniqKey="Brieu Roche N" first="N." last="Brieu-Roche">N. Brieu-Roche</name><name sortKey="Davin Regli, A" sort="Davin Regli, A" uniqKey="Davin Regli A" first="A." last="Davin-Regli">A. Davin-Regli</name><name sortKey="Dunyach Remy, C" sort="Dunyach Remy, C" uniqKey="Dunyach Remy C" first="C." last="Dunyach-Remy">C. Dunyach-Remy</name><name sortKey="Gleize, E" sort="Gleize, E" uniqKey="Gleize E" first="E." last="Gleize">E. Gleize</name><name sortKey="Lamarca, R" sort="Lamarca, R" uniqKey="Lamarca R" first="R." last="Lamarca">R. Lamarca</name><name sortKey="Lavigne, J P" sort="Lavigne, J P" uniqKey="Lavigne J" first="J.-P." last="Lavigne">J.-P. Lavigne</name><name sortKey="Le Coustumier, A" sort="Le Coustumier, A" uniqKey="Le Coustumier A" first="A." last="Le Coustumier">A. Le Coustumier</name><name sortKey="Lecaillon, E" sort="Lecaillon, E" uniqKey="Lecaillon E" first="E." last="Lecaillon">E. Lecaillon</name><name sortKey="Pantel, A" sort="Pantel, A" uniqKey="Pantel A" first="A." last="Pantel">A. Pantel</name><name sortKey="Pantel, A" sort="Pantel, A" uniqKey="Pantel A" first="A." last="Pantel">A. Pantel</name><name sortKey="Prere, M F" sort="Prere, M F" uniqKey="Prere M" first="M.-F." last="Prere">M.-F. Prere</name><name sortKey="Sotto, A" sort="Sotto, A" uniqKey="Sotto A" first="A." last="Sotto">A. Sotto</name><name sortKey="Villeneuve, L" sort="Villeneuve, L" uniqKey="Villeneuve L" first="L." last="Villeneuve">L. 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